Welcome from
Helen Matthews, CEO

As we move into the final weeks of 2025 and reflect, I’m genuinely optimistic that the progress we’ve made this year will have a lasting, positive impact - both on how we test treatments for Parkinson’s, and on our ability to deliver curative treatments for people living with the condition, in the near future.

We are delighted that the biggest ever disease-modifying trial for Parkinson’s in the UK has begun recruitment, with the first two research sites now open. EJS ACT-PD aims to revolutionise clinical trials for Parkinson’s and over the coming months will be seeking participants at over 40 sites around the UK.

This autumn we shared our updated research strategy, which aims to set out a clear pathway to support our goal to identify, test and progress disease-modifying therapies for Parkinson’s.

One of the pillars of the research strategy is a focus on combination therapies, which we believe could have a greater impact on the progression of Parkinson’s. We recently announced a funding call to support trials and preclinical projects in this innovative area of research.

We have long recognised that a cure will only be achieved through collaboration with the whole Parkinson’s community. Each year, the Tom Isaacs Award recognises a researcher who works with the community to drive progress in Parkinson’s research.

This year, we asked you to help us mark our 20th year by taking on walking challenges, concluding with our Walk To Cure Parkinson’s in London. We were truly blown away by the response and have been inspired by your stories, pictures and inventive approaches to the challenge.

To all of you who have made this, the charity’s 20th year, so significant, for your donations, your fundraising and sharing our vision of a world free from Parkinson’s, THANK YOU.

And it’s not over yet. Please consider supporting our Big Give Christmas Challenge. Donations made between 2 and 9 December via the Big Give website will be doubled! And check out our Christmas shop for a wonderful selection of Christmas cards.

Finally, we were incredibly sad to hear the news of Ozzy Osbourne’s passing. A rock legend who lived with Parkinson’s, Ozzy did an enormous amount to raise the profile of the condition and we were honoured to be one of the beneficiary charities of Black Sabbath’s Back to the Beginning show.

Helen Matthews, CEO, Cure Parkinson’s